Solubilization of immune complex in glomerulus
نویسندگان
چکیده
منابع مشابه
Altered Functional Properties of the Renal Glomerulus in Autologous Immune Complex Nephritis
The altered functional properties of the glomerular capillary wall in a model of autologous immune complex disease (Heymann's nephritis) was studied by electron microscopy using intravenously injected protein tracers of varying molecular weight. There was an increase in the permeability of the glomerular basement membrane (GBM) itself to large molecules; this change was focal and was found in t...
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The capacity of complement-mediated solubilization of immune complexes (complex releasing activity: CRA) was studied in 63 sera from eight systemic lupus erythematosus (SLE) patients. CRA in sera of active SLE (35 +/- 17.%) was significantly lower than that of inactive SLE (64.1 +/- 24.1%, P less than 0.001). In addition, 20 of 23 sera collected during active diseases demonstrated CRA values le...
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Immune precipitates were solubilized by the alternative pathway of complement assembled from isolated proteins, i.e., C3, factor B, factor D, properdin, C3b inactivator (C3bINA), and beta 1H. The kinetic curves of solubilization in the isolated system and in EGTA-serum were virtually indistinguishable. No requirement of other factors was apparent. Deletion of C3bINA and beta 1H from the complet...
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Evidence is reviewed that indicates that an immune deficiency state may underlie patients with immune complex nephritis. Studies in several laboratories provide data that show defective immune function in patients with nephritis at the following loci: defective immunoglobulin production, impaired monocyte Fc and C3b receptor function, diminished complement biosynthesis, and decreased mesangial ...
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After enjoying Kettritz’s and Luft’s Nephroquiz [1], I enjoyed even more their reply [2] to my comment, which they ended by posing an interesting dilemma: should we use the terms ‘glomerulus/glomeruli’, masculine gender, or ‘glomerulum/glomerula’, neutral gender? Though I am not a learned scholar (only relying on my four-year high school Latin, long forgotten), I have done some homework and del...
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ژورنال
عنوان ژورنال: Ensho
سال: 1984
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.4.4_357